Santos, Herbert 助教

教育・研究

教員一覧

所属：東京大学大学院医学系研究科国際保健学専攻生物医化学分野
講座：生物医化学
E-mail：hjsantos@m.u-tokyo.ac.jp
Webサイト：https://scholar.google.com/citations?user=Efzae60AAAAJ&hl=en

略歴

2003年4月: Bachelor of Science in Biochemistry, University of the Philippines Manila, Philippines

2003年10月: Teacher, Basic Education Department, San Beda University, Manila, Philippines

2004年10月: Instructor, School of Biological Engineering, Chemical Engineering, and Chemistry, Mapua University, Manila, Philippines

2008年6月: Instructor, Institute of Biology, College of Science, University of the Philippines Diliman, Quezon City, Philippines

2009年4月: Master of Science in Microbiology, University of the Philippines Diliman, Philippines

2010年11月: Assistant Lecturer, Department of Biology, College of Arts and Sciences, Miriam College, Quezon City, Philippines

2015年3月: Doctor of Philosophy in Biological Science, University of Tsukuba, Japan

2015年5月: Postdoctoral Researcher, Graduate School of Life and Environmental Sciences, University of Tsukuba, Ibaraki, Japan

2016年4月: Research Scientist, Department of Parasitology, National Institute of Infectious Diseases, Tokyo, Japan

2018年4月: Assistant Professor, Graduate School of Medicine, Department of International Health, Laboratory of Biomedical Chemistry, The University of Tokyo, Tokyo, Japan

教育

担当授業科目（大学院）
生物医化学特論I、II　╱　熱帯医学特論I、II

初学者向け研究紹介
I have been involved in various research themes involving the human enteric parasite Entamoeba histolytica, particularly on the cell biology and evolution of mitosomes, a class of mitochondrion-related organelle present in this parasite. My previous research theme was focused on the characterization of novel mitosomal β-barrel proteins in E. histolytica. Its major contribution was the discovery of MBOMP30, a novel, Entamoeba-specific, mitosomal outer membrane β-barrel protein. I was also part of collaborations that aimed to better understand the mechanisms involving mitosome fission and protein targeting. Currently, we are collaborating to characterize lineage-specific mitosomal membrane proteins. This endeavor is crucial because membrane proteins are known to play various essential roles in protein and metabolite transport, lipid exchange, organelle dynamics and biogenesis. Recently, a strong trend has emerged towards the investigation of membrane proteins that mediate membrane contact sites, enabling inter- or intra-organelle crosstalk. There is a possibility that our candidate proteins may be lineage-specific receptors, channels, enzymes, or components of novel complexes. Thus, our findings could answer or support new hypotheses on the lack of detectable homologs of key components (e.g. channel protein on the outer membrane, protein import machinery on the inner membrane) in the E. histolytica mitosome. The knowledge generated could support the development of new parasite-specific drugs, as the proteins of interest are Entamoeba-specific. Lastly, I am also involved in the lipidomic profiling and preliminary investigation of fatty acid elongation in E. histolytica as well as the purification and proteomic analysis of E. histolytica exosomes.

初学者向け研究紹介

I have been involved in various research themes involving the human enteric parasite Entamoeba histolytica, particularly on the cell biology and evolution of mitosomes, a class of mitochondrion-related organelle present in this parasite. My previous research theme was focused on the characterization of novel mitosomal β-barrel proteins in E. histolytica. Its major contribution was the discovery of MBOMP30, a novel, Entamoeba-specific, mitosomal outer membrane β-barrel protein. I was also part of collaborations that aimed to better understand the mechanisms involving mitosome fission and protein targeting. Currently, we are collaborating to characterize lineage-specific mitosomal membrane proteins. This endeavor is crucial because membrane proteins are known to play various essential roles in protein and metabolite transport, lipid exchange, organelle dynamics and biogenesis. Recently, a strong trend has emerged towards the investigation of membrane proteins that mediate membrane contact sites, enabling inter- or intra-organelle crosstalk. There is a possibility that our candidate proteins may be lineage-specific receptors, channels, enzymes, or components of novel complexes. Thus, our findings could answer or support new hypotheses on the lack of detectable homologs of key components (e.g. channel protein on the outer membrane, protein import machinery on the inner membrane) in the E. histolytica mitosome. The knowledge generated could support the development of new parasite-specific drugs, as the proteins of interest are Entamoeba-specific. Lastly, I am also involved in the lipidomic profiling and preliminary investigation of fatty acid elongation in E. histolytica as well as the purification and proteomic analysis of E. histolytica exosomes.

研究

研究分野
Parasite cell biology and organelle evolution

現在の研究課題
Discovery and characterization of lineage-specific proteins in Entamoeba histolytica mitosomes

研究内容キーワード
Parasitology　╱　Mitochondrion-related organelles　╱　Membrane proteins　╱　Organelle evolution　╱　Entamoeba histolytica

所属学会
Associate Member, National Research Council, Department of Science and Technology (DOST), Philippines　╱　Member, Phi Sigma Biological Sciences Honor Society, Alpha Chi Chapter, Philippines

著書(10件まで)
Makiuchi T, Santos H, Tachibana H, Nozaki, T. Hetero-oligomer of dynamin-related proteins participates in the fission of highly divergent mitochondria from Entamoeba histolytica. Scientific Reports, 7,13439, 2017 Santos H, Imai K, Hanadate Y, Fukasawa Y, Oda T, Mi-ichi F, Nozaki T. Screening and discovery of lineage-specific mitosomal membrane proteins in Entamoeba histolytica. Molecular and Biochemical Parasitology, 209:1-2, 10-17, 2016 Santos H, Imai K, Makiuchi T, Tomii K, Horton P, Nozawa A, Ibrahim M, Tozawa Y, Nozaki T. A Novel Mitosomal β-Barrel Outer Membrane Protein in Entamoeba. Scientific Reports, 5, 8545, 2015 * equal contribution

著書(10件まで)

Makiuchi T, Santos H, Tachibana H, Nozaki, T. Hetero-oligomer of dynamin-related proteins participates in the fission of highly divergent mitochondria from Entamoeba histolytica. Scientific Reports, 7,13439, 2017
Santos H, Imai K, Hanadate Y, Fukasawa Y, Oda T, Mi-ichi F, Nozaki T. Screening and discovery of lineage-specific mitosomal membrane proteins in Entamoeba histolytica. Molecular and Biochemical Parasitology, 209:1-2, 10-17, 2016
Santos H*, Imai K*, Makiuchi T, Tomii K, Horton P, Nozawa A, Ibrahim M, Tozawa Y, Nozaki T. A Novel Mitosomal β-Barrel Outer Membrane Protein in Entamoeba. Scientific Reports, 5, 8545, 2015 * equal contribution

その他

趣味

food tripping, travelling, running

座右の銘

Be an inspiration to others through your kindness.

将来の夢

That opportunities become more accessible especially to the underprivileged

学生への一言

Do not ever let failure bring you down. Make it a motivation to strive harder in order to achieve your goals.