教育・研究

教員一覧

Santos, Herbert  助教

所属:東京大学大学院医学系研究科 国際保健学専攻 生物医化学分野
講座:生物医化学
E-mail:hjsantos@m.u-tokyo.ac.jp
Webサイト:https://scholar.google.com/citations?user=Efzae60AAAAJ&hl=en

略歴

2003年4月
Bachelor of Science in Biochemistry, University of the Philippines Manila, Philippines
2003年10月
Teacher, Basic Education Department, San Beda University, Manila, Philippines
2004年10月
Instructor, School of Biological Engineering, Chemical Engineering, and Chemistry, Mapua University, Manila, Philippines
2008年6月
Instructor, Institute of Biology, College of Science, University of the Philippines Diliman, Quezon City, Philippines
2009年4月
Master of Science in Microbiology, University of the Philippines Diliman, Philippines
2010年11月
Assistant Lecturer, Department of Biology, College of Arts and Sciences, Miriam College, Quezon City, Philippines
2015年3月
Doctor of Philosophy in Biological Science, University of Tsukuba, Japan
2015年5月
Postdoctoral Researcher, Graduate School of Life and Environmental Sciences, University of Tsukuba, Ibaraki, Japan
2016年4月
Research Scientist, Department of Parasitology, National Institute of Infectious Diseases, Tokyo, Japan
2018年4月
Assistant Professor, Graduate School of Medicine, Department of International Health, Laboratory of Biomedical Chemistry, The University of Tokyo, Tokyo, Japan

教育

担当授業科目(大学院)
生物医化学特論I、II ╱ 熱帯医学特論I、II
初学者向け研究紹介
I have been involved in various research themes involving the human enteric parasite Entamoeba histolytica, particularly on the cell biology and evolution of mitosomes, a class of mitochondrion-related organelle present in this parasite. My previous research theme was focused on the characterization of novel mitosomal β-barrel proteins in E. histolytica. Its major contribution was the discovery of MBOMP30, a novel, Entamoeba-specific, mitosomal outer membrane β-barrel protein. I was also part of collaborations that aimed to better understand the mechanisms involving mitosome fission and protein targeting. Currently, we are collaborating to characterize lineage-specific mitosomal membrane proteins. This endeavor is crucial because membrane proteins are known to play various essential roles in protein and metabolite transport, lipid exchange, organelle dynamics and biogenesis. Recently, a strong trend has emerged towards the investigation of membrane proteins that mediate membrane contact sites, enabling inter- or intra-organelle crosstalk. There is a possibility that our candidate proteins may be lineage-specific receptors, channels, enzymes, or components of novel complexes. Thus, our findings could answer or support new hypotheses on the lack of detectable homologs of key components (e.g. channel protein on the outer membrane, protein import machinery on the inner membrane) in the E. histolytica mitosome. The knowledge generated could support the development of new parasite-specific drugs, as the proteins of interest are Entamoeba-specific. Lastly, I am also involved in the lipidomic profiling and preliminary investigation of fatty acid elongation in E. histolytica as well as the purification and proteomic analysis of E. histolytica exosomes.

研究

研究分野
Parasite cell biology and organelle evolution
現在の研究課題
Discovery and characterization of lineage-specific proteins in Entamoeba histolytica mitosomes
研究内容キーワード
Parasitology ╱ Mitochondrion-related organelles ╱ Membrane proteins ╱ Organelle evolution ╱ Entamoeba histolytica
所属学会
Associate Member, National Research Council, Department of Science and Technology (DOST), Philippines ╱ Member, Phi Sigma Biological Sciences Honor Society, Alpha Chi Chapter, Philippines
著書(10件まで)
  1. Makiuchi T, Santos H, Tachibana H, Nozaki, T. Hetero-oligomer of dynamin-related proteins participates in the fission of highly divergent mitochondria from Entamoeba histolytica. Scientific Reports, 7,13439, 2017
  2. Santos H, Imai K, Hanadate Y, Fukasawa Y, Oda T, Mi-ichi F, Nozaki T. Screening and discovery of lineage-specific mitosomal membrane proteins in Entamoeba histolytica. Molecular and Biochemical Parasitology, 209:1-2, 10-17, 2016
  3. Santos H*, Imai K*, Makiuchi T, Tomii K, Horton P, Nozawa A, Ibrahim M, Tozawa Y, Nozaki T. A Novel Mitosomal β-Barrel Outer Membrane Protein in Entamoeba. Scientific Reports, 5, 8545, 2015 * equal contribution

その他

趣味

food tripping, travelling, running

座右の銘

Be an inspiration to others through your kindness.

将来の夢

That opportunities become more accessible especially to the underprivileged

学生への一言

Do not ever let failure bring you down. Make it a motivation to strive harder in order to achieve your goals.